Combining the above post: (1) If one would eliminate the path of moisture movement to the space in question, there should be problem. (Air sealing, vapor retarders, proper site drainage & crawl space elevation in relationship to the exterior grade) (2.) Condition the space in question. (Mechanically control the temp.relative humidity and ventilation)there should be no problem. No hole - No moisture - No problem. Crawl space vents might be alright if they were controlled mechanically. Opened or closed depending upon the specific conditions of the temp. and relative humidity of both the outside air and the inside air of the crawl space. Practical maybe not. I like the condition crawl space theory myself. That is until one of can convince me other wise.